Dopamine deficiency in the weaver mutant mouse
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چکیده
منابع مشابه
Dopamine Deficiency in the Weaver Mutant Mouse1
The dopamine system in weaver mutant mice (BGCBA-AwmJ/A background) was studied. Dopamine was 27% lower in the olfactory tubercle, 77% lower in the frontal cortex, and 75% lower in the striatum of 6-month-old weaver mice compared to control mice of the same age. Norepinephrine and serotonin were not lower in these brain areas. Tyrosine hydroxylase activity in the striatum was measured with a ra...
متن کاملThe weaver mutation reverses the function of dopamine and GABA in mouse dopaminergic neurons.
In the present study, we characterized the intrinsic electrophysiological properties and the membrane currents activated by dopamine (DA) D(2) and GABA(B) receptors in midbrain dopaminergic neurons, maintained in vitro in a slice preparation, from wild-type and homozygous weaver (wv/wv) mice. By using patch-clamp techniques, we found that membrane potential, apparent input resistance, and spont...
متن کاملCerebellar Alterations in the Weaver Mouse
The fine structure of the cerebellum of weaver mouse was examined and the paucity of granule cells and their axons, the parallel fibers, was confirmed. Unexpectedly, however, the dendritic spines of the Purkinje cells which, in normal animals, are the postsynaptic mates of the parallel fibers, were present. Furthermore, their essential morphology and their staining reactions were indistinguisha...
متن کاملPatterns of cell and fiber vulnerability in the mesostriatal system of the mutant mouse weaver. II. High affinity uptake sites for dopamine.
Weaver (gene symbol wv) is an autosomal recessive mutation in the mouse that causes the death of neurons in the cerebellum and of dopamine-containing neurons in the mid-brain. In the accompanying paper and in previous reports, the selective nature of the deficit produced by the gene in the dopamine-containing systems has been described after analysis of the patterns of the residual innervation ...
متن کاملFunctional Analysis of the weaver Mutant GIRK2 K+ Channel and Rescue of weaver Granule Cells
In the neurological mutant mouse weaver, granule cell precursors proliferate normally in the external germinal layer of the cerebellar cortex, but fail to differentiate. Granule neurons purified from weaver cerebella have greatly reduced G protein-activated inwardly rectifying K+ currents; instead, they display a constitutive Na+ conductance. Expression of the weaver GIRK2 channel in oocytes co...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1982
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.02-03-00376.1982